AMGEN TO PRESENT NEW exploration ACROSS SERIOUS seditious AND BONE conditions AT ACR 2022
New Real- World substantiation Highlights AMGEVITA ® Application, Treatment Satisfaction and continuity in European Cases
New Data From First- in- Class Treatment TAVNEOS ®, assessing Renal Function Among Grown-ups Living With Severe Active ANCA- Associated Vasculitis
Amgen( NASDAQAMGN) moment blazoned that clinical and real- world data across its broad portfolio of established treatments and channel means will be presented at the periodic American College of Rheumatology Convergence( ACR), taking place in Philadelphia onNov. 10- 14, 2022.
Among 25 objectifications, noteworthy donations will include real- world substantiation for AMGEVITA ® *( adalimumab), emphasizing treatment satisfaction and continuity in German cases with rheumatic conditions. fresh data will punctuate application in European cases with moderate to severe rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis.
Other Exploration highlights include data on TAVNEOS ®( avacopan) in severe activeanti-neutrophil cytoplasmic autoantibody( ANCA)- associated vasculitis, specially an oral donation on evaluation of recovery of renal function among cases with birth estimated glomerular filtration rate( eGFR) at or below 20; renal function is bloodied in the maturity of people with the complaint. also, two real- world substantiation bills report on the goods of Otezla ®( apremilast) on cardiometabolic parameters in cases with psoriatic complaint.
” Given the uptake of biosimilars, we’re looking forward to presenting real- world substantiation data from the gests of cases using AMGEVITA, since it was approved in Europe four times agone
,” said DavidM. Reese,M.D., administrative vice chairman of Research and Development at Amgen.” The breadth of data being presented reflects our deep commitment to driving invention in seditious conditions.”
- AMJEVITA ™ outside the US is retailed as AMGEVITA. AMJEVITA is presently not available commercially and won’t be commercially available in the United States until on or after January 31, 2023.
ABOUT AMJEVITA ®( adalimumab- atto) in theU.S.
AMJEVITA is a biosimilar to adalimumab, ananti-TNF-α monoclonal antibody. The active component of AMJEVITA is ananti-TNF-α monoclonal antibody that has the same amino acid sequence as, and is largely analogous to, adalimumab. AMJEVITA will be delivered in prefilled hype
and autoinjector donations to support dosing in each of the approved suggestions.
AMJEVITA isn’t presently available commercially. This not an offer for trade. The following information is deduced from the approved marker. AMJEVITA is indicated, alone or in combination with methotrexate or othernon-biologic DMARDs, for reducing signs and symptoms, converting major clinical response, inhibiting the progression of structural damage, and perfecting physical function in adult cases with relatively to oppressively active rheumatoid arthritis.
AMJEVITA is indicated, alone or in combination with methotrexate, for reducing signs and symptoms of relatively to oppressively active polyarticular juvenile idiopathic arthritis in cases 4 times of age and aged. AMJEVITA is indicated, alone or in combination withnon-biologic DMARDs, for reducing signs and symptoms, inhibiting the progression of structural damage, and perfecting physical function in adult cases with active psoriatic arthritis.
AMJEVITA is indicated for reducing signs and symptoms in adult cases with active ankylosing spondylitis. About ENBREL( etanercept)
ENBREL is a answerable form of a excrescence necrosis factor( TNF) receptor with a clinical efficacity and safety profile established over 20 times of collaborative clinical experience. ENBREL was first approved in 1998 for moderate- to-severe rheumatoid arthritis. ENBREL was approved in 1999 to treat moderate- to-severe polyarticular juvenile idiopathic arthritis, in 2002 to treat psoriatic arthritis, in 2003 for the treatment of cases with ankylosing spondylitis, in 2004 to treat moderate- to-severe shrine psoriasis in grown-ups, and in 2016 the moderate- to-severe shrine psoriasis suggestion was expanded to include cases 4 times or aged. tradition ENBREL is given by injection.
About EVENITY ®( romosozumab- aqqg)
EVENITY is a bone- structure humanized monoclonal antibody. It’s designed to work by inhibiting the exertion of sclerostin, which contemporaneously results in increased bone conformation and to a lower extent dropped bone resorption. The EVENITY development program includes 19 clinical studies that enrolled further than,000 cases. EVENITY has been studied for its eventuality to reduce the threat of fractures in an expansive global Phase 3 program that included two large fracture trials comparing EVENITY to either placebo or active comparator in nearly,000 postmenopausal women with osteoporosis. Amgen and UCB areco-developing EVENITY.
About TAVNEOS ®( avacopan)
TAVNEOS( avacopan), approved by the FDA as an spare treatment for grown-ups with severe active ANCA- associated vasculitis, is a first- in- class, orally administered small patch that employs a novel, largely targeted mode of action in complement- driven autoimmune and seditious conditions. While the precise medium in ANCA- associated vasculitis has not been definitively established, TAVNEOS, by blocking the complement 5a receptor( C5aR) for thepro-inflammatory complement system scrap known as C5a on destructive seditious cells similar as blood neutrophils, is presumed to arrest the capability of those cells to do damage in response to C5a activation, which is known to be the motorist of ANCA- associated vasculitis.
Amgen is committed to unleashing the eventuality of biology for cases suffering from serious ails by discovering, developing, manufacturing and delivering innovative mortal rectifiers. This approach begins by using tools like advanced mortal genetics to unravel the complications of complaint and understand the fundamentals of mortal biology. Amgen focuses on areas of high unmet medical need and leverages its moxie to strive for results that ameliorate health issues and dramatically ameliorate people’s lives. A biotechnology colonist since 1980, Amgen has grown to be one of the world’s leading independent biotechnology companies, has reached millions of cases around the world and is developing a channel of drugs with breakaway eventuality. Amgen is one of the 30 companies that comprise the Dow Jones Industrial Average and is also part of the Nasdaq- 100 indicator. In 2022, Amgen was named one of the” World’s Stylish Employers” by Forbes and one of” America’s 100 utmost Sustainable Companies” by Barron’s.