
Novotech Report Highlights Surge in siRNA Research with 150+ Clinical Trials (2020-2024)
Novotech, a globally recognized full-service clinical research organization (CRO) and scientific advisory company, has released its latest preclinical report exploring the rapidly evolving landscape of small interfering RNA (siRNA) therapeutics. This report provides biotech and pharmaceutical companies with key insights into the expanding role of RNA-based precision medicine in developing next-generation treatments for oncology, metabolic disorders, and rare genetic diseases.
Unlocking the Potential of siRNA in Drug Development
siRNA therapeutics represent a paradigm shift in targeted drug development, offering precise gene silencing capabilities to modulate disease-causing genes effectively. Unlike traditional small-molecule drugs and monoclonal antibodies, siRNA-based therapies operate at the genetic level, allowing for highly specific and durable treatment effects. With the FDA’s approval of multiple siRNA-based drugs, including ONPATTRO™ (Patisiran) for hereditary transthyretin amyloidosis and Inclisiran for hypercholesterolemia, the field has seen significant advancements in delivery platforms, stability, and tissue-specific targeting.
Novotech’s report underscores how siRNA technologies are broadening the scope of the druggable genome by targeting previously inaccessible molecular pathways. The ongoing clinical development of siRNA therapeutics signals a major shift in the pharmaceutical landscape, addressing a growing number of therapeutic areas with high unmet medical needs.

Key Highlights from the Report
1. Clinical and Regulatory Landscape
The report provides an in-depth overview of the siRNA regulatory landscape, detailing the approval of six siRNA-based therapies by the U.S. Food and Drug Administration (FDA). These approved treatments are expanding their indications into cardiovascular, hepatic, and rare genetic disorders, demonstrating the versatility of siRNA in precision medicine. With regulatory agencies offering accelerated pathways and orphan drug designations, siRNA drug development is gaining substantial momentum.
2. Advances in siRNA Delivery Technologies
One of the primary challenges in siRNA therapeutics has been efficient and safe delivery to target tissues. Novotech’s report highlights key advancements in delivery technologies that are addressing these challenges:
- Lipid Nanoparticles (LNPs): Enabling systemic delivery of siRNA molecules, particularly for liver-targeted therapies.
- GalNAc Conjugates: Facilitating targeted hepatic delivery with enhanced stability and minimal immune activation.
- Polymeric and Peptide-Based Nanoparticles: Expanding siRNA’s applicability to extrahepatic targets, including cancer and central nervous system disorders.
These innovations are improving bioavailability, reducing off-target effects, and enhancing therapeutic efficacy, making siRNA a viable option for a broader range of diseases.
3. Expanding Applications in Oncology
The application of siRNA in oncology is a rapidly growing area of interest, with numerous preclinical and clinical studies evaluating its potential in cancer treatment. The report outlines several key mechanisms by which siRNA is transforming oncology research:
- Silencing Oncogenes: Directly inhibiting tumor-driving genes to suppress cancer progression.
- Overcoming Drug Resistance: Targeting resistance-associated pathways to improve response to chemotherapy and targeted therapies.
- Modulating the Tumor Microenvironment: Regulating immune and stromal interactions to enhance anti-tumor immunity.
With these advancements, siRNA therapeutics are positioning themselves as a promising alternative to traditional cancer treatments, including chemotherapy and immune checkpoint inhibitors.
4. Clinical Trial Growth and Future Outlook
The report presents a detailed analysis of the 150+ industry-sponsored siRNA clinical trials conducted between 2020 and 2024. The findings reveal a remarkable 79.5% compound annual growth rate (CAGR) in siRNA-related clinical trials, reflecting substantial industry investment and a strong commitment to advancing RNA-based therapies.
Several key trends are highlighted:
- Expansion into New Indications: Clinical trials are extending beyond traditional liver-based disorders into areas such as oncology, neurology, and inflammatory diseases.
- Improved Patient Outcomes: Early-phase data indicate durable therapeutic responses with manageable safety profiles.
- Strategic Partnerships and Collaborations: Increased industry-academic collaborations to accelerate innovation and optimize siRNA delivery platforms.
The growing body of clinical evidence underscores the potential of siRNA to revolutionize treatment paradigms across multiple therapeutic areas, reinforcing its status as a leading platform in next-generation drug development.
Partnering for Success in siRNA Clinical Development
As a leading global provider of end-to-end clinical trial services, Novotech collaborates with biotech and pharmaceutical innovators to streamline siRNA drug development. Leveraging over 25 years of experience in clinical trial execution, Novotech provides:
- Comprehensive Regulatory Guidance: Ensuring compliance with evolving global regulatory requirements to facilitate faster approvals.
- Strategic Site Selection: Identifying high-recruitment sites with expertise in RNA-based therapeutics.
- Expert Trial Management: Navigating the complexities of siRNA clinical research to enhance efficiency and trial success rates.
Through its extensive experience in RNA research, Novotech empowers drug developers to navigate the evolving siRNA landscape with confidence, accelerating the path from discovery to market approval.