Possible target for treating and preventing osteoarthritis found in little-studied protein

Wear and tear on joints can lead to inflammation, breakdown of cartilage and development of osteoarthritis. Scientists at UF Scripps Biomedical Research have set up a possible new target to fight this painful waterfall.
In a study published Thursday in the journal PLOS One, biochemist Patrick Griffin,Ph.D., and coworker Mi Ra Chang,Ph.D., describe a specific protein that manages conditioning within chondrocytes, a critical cell type that maintains healthy cartilage in joints.

As people age and stress their joints, their chondrocytes begin to fail. The UF Scripps platoon set up that cranking a specific protein in these cells called RORβ( beta) could restore multiple factors demanded for smooth joints to healthier situations, helping to control inflammation. cranking RORβ could therefore present a useful new strategy to help or delay development of the degenerative common complaint osteoarthritis, said Griffin, a professor of molecular drug and scientific director of UF Scripps Biomedical Research.

” People need an osteoarthritis drug that addresses the root cause of cartilage damage and reduction as there presently are no complaint- modifying medicines for what’s theNo. 1 cause of disability in the United States,” Griffin said.” While our work is in the early stages, our study suggests that the nuclear receptor RORβ could present a new remedial target to cover cartilage damage and maybe turn on cartilage rejuvenescence.”

RORβ, short for” retinoic acid receptor- related orphan receptor beta,” is a type of protein called a nuclear receptor. In our cells, genes switch between ages of exertion and inactivity. When nuclear receptors bind to DNA, that activates the cell’s process of transcribing genes into proteins. RORβ has been linked to development of the eye’s retina during fetal growth, and it can impact circadian measures by controlling timepiece genes. But its part in maintaining cartilage health was unclear.

Griffin has studied causes of bone conditions for numerous times. He zeroed in on RORβ for several reasons. While many studies have been concentrated on this receptor, some had shown correlation between the receptor’s exertion and bone loss. So he and Chang set out to more understand it. Chang finagled cell lines to enable the studies.

” To our surprise, the gene program upregulated by increase in RORβ exertion was probative of the conformation of chondrocytes,anti-inflammatory, and defensive against cartilage declination,” Chang said.

Griffin said the platoon has launched fresh studies because of the enormous need for osteoarthritis results. In the United States, an estimated 32 million people live with the painful condition.

” This study suggests RORβ could be an seductive remedial target. still, there is much further we need to unravel,” Griffin said.” Specifically, we want to understand further about the medium by which RORβ impacts chondrocytes and blunts the seditious signals that lead to cartilage destruction.”

Chang MR, Griffin PR.
RORβ modulates a gene program that’s defensive against articular cartilage damage.
PLoS One. 2022 Oct 13; 17( 10) e0268663. doi10.1371/journal.pone.0268663

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